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Two challenges limit the convenience of switching from one particular troponin assay to another in medical observe or research. First, no Principal reference cTnI material is available for manufacturers to standardize cTnI assays.
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Cardiac troponin T as a marker for myocardial ischemia in individuals seen for the crisis Section for acute chest ache.[Am Heart J. 1999]
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Autoantibodies also have the possible to result in interference in troponin immunometric assay solutions. Wrong-optimistic or Wrong-unfavorable values might occur, depending on if the autoantibody-analyte advanced partitions into the absolutely free or the sure analyte fraction.
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